Vitamin K2 (MK-7)
Commonly used for
Healthy AgingHeart HealthBone Health
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What is it? / Overview
Vitamin K2 activates proteins involved in directing calcium into bones rather than soft tissues. It is commonly paired with vitamin D in people focused on bone health and often overlooked as a complement to calcium supplementation.
How is it used? / Administration
Form: Menaquinone-7 (MK-7)
Typical dose studied: 90–180 mcg/day
Timing: With fat-containing meal
MK-7 has a longer half-life than MK-4. Often paired with vitamin D3 for synergistic bone health benefit.
What does it pair with?
Pairs well with:
Frequently combined for bone and calcium support, but not required together — Often formulated together, but evidence doesn't establish that everyone taking vitamin D must also take K2.
How well does it work? / Evidence
~ Moderate evidence
Who should avoid it?
Interacts with: Warfarin and vitamin K antagonists — maintain consistent intake only under physician guidance
Already taking it? MK-7 has longer half-life than MK-4 — maintain consistent daily dosing.
Research & references
Knapen MHJ et al. Vitamin K2 and bone. EFSA Scientific Opinion on Vitamin K. NIH ODS Vitamin K Fact Sheet.
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