Riboflavin (Vitamin B2)
Commonly used for
EnergyFocusMigraine
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What is it? / Overview
Riboflavin is essential for mitochondrial energy production. High-dose supplementation has good evidence for reducing migraine frequency in some individuals while standard doses prevent deficiency.
How is it used? / Administration
Form: Riboflavin
Typical dose studied: 200–400 mg/day for migraine prevention; 1.1–1.3 mg/day for nutritional needs
Timing: With meals
Takes approximately 2–3 months to assess effectiveness for migraine prevention. Bright yellow urine is harmless.
How well does it work? / Evidence
✓ Well-established
Who should avoid it?
Already taking it? Bright yellow urine is a harmless expected effect.
Research & references
American Headache Society Guidance on Riboflavin. Schoenen J et al. Riboflavin and migraine. NIH ODS: Riboflavin Fact Sheet.
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