Pterostilbene
Commonly used for
Healthy Aging
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What is it? / Overview
Wellness uses some people report: brain anti-aging and general longevity. This is anecdotal, and there isn't strong clinical evidence that it works for everyone. Pterostilbene activates SIRT1 and Nrf2 signaling, raising endogenous antioxidants and lowering pro-inflammatory cytokines in preclinical models, with neuroprotective effects in animal studies -- but robust human longevity or cognition trial evidence is still lacking, and one small trial noted a possible LDL increase at higher doses.
How is it used? / Administration
Form: Pterostilbene (trans-3,5-dimethoxy-4'-hydroxystilbene, from blueberries) -- a more bioavailable resveratrol analogue, often paired with NMN/NR in longevity stacks
Typical dose studied: 50-125 mg/day (up to 250 mg studied for lipids)
Timing: With food
Limited safety data overall -- reasonable caution in pregnancy given the general lack of data, even though that can't be captured as a matched condition given how this platform handles pregnancy (see Vinpocetine's notes above for the same structural gap).
How well does it work? / Evidence
? Emerging / limited evidence
Who should avoid it?
Avoid with: High cholesterol / Hyperlipidemia
Already taking it? Robust human longevity or cognition trials are lacking -- reasonable to continue at label doses, but keep an eye on lipid panels given a possible LDL-raising signal at higher doses in the one available small trial.
Research & references
Hassani B et al. (2022). Pharmacological Approaches to Decelerate Aging: A Promising Path. Oxidative Medicine and Cellular Longevity. Dutta BJ et al. (2023). Unlocking the Therapeutic Potential of Natural Stilbene: Exploring Pterostilbene as a Powerful Ally Against Aging and Cognitive Decline. Ageing Research Reviews.
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