PQQ (Pyrroloquinoline Quinone)
Commonly used for
FocusHealthy AgingEnergy
Wellness uses
'growing new mitochondria' and general anti-aging
This is anecdotal, and there isn't strong clinical evidence that it works for everyone.
What is it? / Overview
PQQ is a redox-active compound that may support mitochondrial function and reduce oxidative stress. Early human studies suggest potential benefits for fatigue and cognitive function, but evidence remains limited compared with more established supplements.
How is it used? / Administration
Form: Pyrroloquinoline quinone disodium salt
Typical dose studied: 10–20 mg/day
Timing: Morning with food
Human evidence still emerging. Often combined with CoQ10 though evidence for the combination is limited.
How well does it work? / Evidence
? Emerging / limited evidence
Who should avoid it?
Avoid with: Breastfeeding
Already taking it? Reassess benefit after 8–12 weeks.
Research & references
Nakano M et al. (2012). Effects of oral supplementation with pyrroloquinoline quinone on stress, fatigue, and sleep. Functional Foods in Health and Disease. Harris CB et al. (2013). Dietary PQQ and inflammation/mitochondrial metabolism. Journal of Nutritional Biochemistry. Rucker R et al. (2009). Potential physiological importance of pyrroloquinoline quinone. Altern Med Rev.