PQQ (Pyrroloquinoline Quinone)

Commonly used for

FocusHealthy AgingEnergy

What is it? / Overview

Wellness uses some people report: 'growing new mitochondria' and general anti-aging. This is anecdotal, and there isn't strong clinical evidence that it works for everyone. PQQ is a redox-active compound that may support mitochondrial function and reduce oxidative stress. Early human studies suggest potential benefits for fatigue and cognitive function, but evidence remains limited compared with more established supplements.

How is it used? / Administration

Form: Pyrroloquinoline quinone disodium salt

Typical dose studied: 10–20 mg/day

Timing: Morning with food

Human evidence still emerging. Often combined with CoQ10 though evidence for the combination is limited.

How well does it work? / Evidence

? Emerging / limited evidence

Who should avoid it?

Avoid with: Breastfeeding

Already taking it? Reassess benefit after 8–12 weeks.

Research & references

Nakano M et al. (2012). PQQ and fatigue and sleep in healthy adults. Journal of Nutritional Science and Vitaminology. Harris CB et al. (2013). Dietary PQQ and inflammation/mitochondrial metabolism. Journal of Nutritional Biochemistry. Rucker R et al. (2009). Physiological importance of PQQ review. Alternative Medicine Review.