Phosphatidylserine
Commonly used for
FocusHealthy AgingAthletic Performance
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What is it? / Overview
Wellness uses some people report: general cortisol and stress support. This is anecdotal, and there isn't strong clinical evidence that it works for everyone. Phosphatidylserine is a phospholipid found in cell membranes particularly in the brain. It may modestly support memory, attention, and stress recovery especially in older adults or those under prolonged physical stress.
How is it used? / Administration
Form: Soy- or sunflower-derived phosphatidylserine
Typical dose studied: 200–300 mg/day
Timing: With meals
Benefits tend to be modest and gradual. Often combined with other nootropics for cognitive support.
How well does it work? / Evidence
? Emerging / limited evidence
Who should avoid it?
Interacts with: Anticholinergic medications — consult clinician
Already taking it? Assess after 8–12 weeks of consistent use.
Research & references
Glade MJ, Smith K. (2015). Phosphatidylserine and the human brain. Nutrition. Kingsley MI et al. (2006). PS and exercise capacity cycling. Medicine & Science in Sports & Exercise. Richter Y et al. (2013). Soy-derived PS and cognitive performance in elderly. Clinical Interventions in Aging.
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