PEA (Palmitoylethanolamide)
Commonly used for
InflammationHealthy AgingNerve Health
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What is it? / Overview
PEA is an endogenous fatty acid amide that helps regulate neuroinflammation and pain signaling by modulating mast cells and glial cells. Clinical studies suggest it may reduce neuropathic and chronic pain with a favorable safety profile.
How is it used? / Administration
Form: Micronized or ultramicronized palmitoylethanolamide
Typical dose studied: 600 mg once or twice daily (600–1,200 mg/day)
Timing: With or without food
Micronized and ultramicronized formulations have the strongest clinical evidence. Best used as an adjunct to conventional pain management.
How well does it work? / Evidence
~ Moderate evidence
Who should avoid it?
Avoid with: Breastfeeding
Already taking it? Evaluate response after 6–8 weeks before continuing long term.
Research & references
Paladini A et al. (2016). PEA for chronic pain pooled meta-analysis. Pain Physician. Steels E et al. (2019). PEA double-blind RCT for chronic pain. Inflammopharmacology. Keppel Hesselink JM et al. (2013). PEA as natural anti-inflammatory compound. Journal of Pain Research.
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