Mucuna pruriens
Commonly used for
FocusLibidoEnergy
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What is it? / Overview
Mucuna naturally contains L-DOPA, the direct precursor to dopamine. Human studies suggest possible improvements in sperm quality and fertility markers, but evidence in healthy individuals for cognition, mood, or testosterone is limited.
How is it used? / Administration
Form: Standardized seed extract (standardized for L-DOPA content, typically 15–20%)
Typical dose studied: 250–500 mg/day standardized extract
Timing: Morning or early afternoon, empty stomach if tolerated
IMPORTANT: significant interaction risk with Parkinson's medications and antipsychotics due to dopaminergic activity. Primarily relevant for male fertility research.
How well does it work? / Evidence
~ Moderate evidence
Who should avoid it?
Avoid with: Parkinson disease; Cancer — active or within past 12 months; Schizophrenia / Psychotic disorder
Interacts with: Levodopa; MAO inhibitors; Antipsychotics; Dopamine agonists
Already taking it? Avoid combining with prescription dopaminergic medications without physician supervision.
Research & references
Shukla KK et al. (2010). Mucuna pruriens and male fertility/oxidative stress RCT. Fertility and Sterility. Lampariello LR et al. (2012). Mucuna pruriens review. Journal of Traditional and Complementary Medicine. Manyam BV. (1995). Alternative medicine treatment for Parkinson's disease multicenter trial. Journal of Alternative and Complementary Medicine.
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