MSM (Methylsulfonylmethane)
Commonly used for
InflammationHealthy AgingAthletic Performance
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What is it? / Overview
MSM is an organosulfur compound that may reduce inflammation and oxidative stress while supporting connective tissue health. Clinical trials suggest modest improvements in pain and physical function in people with osteoarthritis.
How is it used? / Administration
Form: Methylsulfonylmethane
Typical dose studied: 1.5–6 g/day (commonly 3 g/day divided into 2 doses)
Timing: With meals; divide larger doses
GI side effects generally mild. Often stacked with glucosamine, chondroitin, or curcumin for joint health.
How well does it work? / Evidence
~ Moderate evidence
Who should avoid it?
Avoid with: Breastfeeding
Interacts with: Anticoagulants — theoretical caution
Already taking it? Assess benefit after 8–12 weeks. Often combined with glucosamine and/or chondroitin.
Research & references
Brien S et al. (2008). MSM in osteoarthritis systematic review. Osteoarthritis and Cartilage. Kim LS et al. (2006). MSM in knee osteoarthritis pilot trial. Osteoarthritis and Cartilage. Chen C et al. (2025). Dietary supplements for osteoarthritis network meta-analysis. Journal of Integrative Medicine.
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