Milk Thistle (Silymarin)
Commonly used for
Liver Support
Where to Buy
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What is it? / Overview
Silymarin has antioxidant and possible liver-cell-protective properties in laboratory and some clinical studies, though outcome evidence in liver disease remains inconsistent. Fatigue not relieved by rest is included as a narrow trigger given some supporting evidence, but this remains a modest, secondary use — abnormal liver function or persistent related symptoms should still prompt medical evaluation, not self-directed supplementation alone.
How is it used? / Administration
Form: Standardized extract (70–80% silymarin)
Typical dose studied: 140 mg, 2–3 times daily
Timing: With meals
Evidence for meaningful clinical outcomes remains inconsistent overall — this is a modest, narrowly-triggered entry, not a broadly recommended one. Cross-reactive allergy possible in people sensitive to ragweed, daisies, or related plants.
How well does it work? / Evidence
? Emerging / limited evidence
Who should avoid it?
Interacts with: Diabetes medications; Statins
Already taking it? Should complement — not replace — medical evaluation and addressing the underlying cause of any liver concern (alcohol use, fatty liver, viral hepatitis, medication effects, etc.).
Research & references
Federico A et al. Silymarin and liver disease — review. Saller R et al. Systematic review of silymarin for liver diseases.
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