Melatonin Extended-Release
Commonly used for
SleepNighttime AwakeningsInsomnia
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The cheapest product is usually low quality, but more expensive doesn’t always mean better.
What is it? / Overview
Unlike immediate-release melatonin, prolonged-release formulations mimic the body's natural overnight melatonin secretion making them particularly helpful for people who fall asleep easily but wake frequently during the night. Evidence is strongest in adults over 55.
How is it used? / Administration
Form: Prolonged-release (extended-release) melatonin
Typical dose studied: 2 mg nightly
Timing: 1–2 hours before bedtime
Best for sleep maintenance rather than sleep onset. Continue emphasizing good sleep hygiene alongside.
How well does it work? / Evidence
~ Moderate evidence
Who should avoid it?
Avoid with: Breastfeeding; Organ transplant (on immunosuppression)
Interacts with: Sedatives; Anticoagulants; Immunosuppressants
Already taking it? Use lowest effective dose. Periodically reassess need for continued use.
Research & references
Wade AG et al. (2007). Prolonged-release melatonin in insomnia ages 55–80. Current Medical Research and Opinion. Lemoine P et al. (2012). Prolonged-release melatonin evidence-based review. Therapeutics and Clinical Risk Management. Riemann D et al. (2023). European guideline for insomnia. Journal of Sleep Research.
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