Manganese

Commonly used for

Healthy AgingWound HealingBone Health

What is it? / Overview

Manganese is a trace mineral required for antioxidant enzymes, bone formation, cartilage development, and normal carbohydrate metabolism. True deficiency is extremely rare because adequate amounts are typically obtained through diet.

How is it used? / Administration

Form: Manganese bisglycinate or manganese gluconate

Typical dose studied: 2–5 mg/day for deficiency. Adequate Intake: 1.8 mg/day (women), 2.3 mg/day (men)

Timing: With meals

Deficiency is exceptionally uncommon outside severe malnutrition or prolonged TPN. Excess manganese can be neurotoxic, particularly with impaired liver function. Routine supplementation NOT recommended without confirmed deficiency.

How well does it work? / Evidence

✓ Well-established

Who should avoid it?

Avoid with: End-stage liver disease / Cirrhosis

Interacts with: Separate from high-dose calcium, iron, or magnesium — reduces absorption

Already taking it? Avoid unnecessary supplementation once deficiency is corrected.

Research & references

Aschner M et al. (2009). Manganese and Parkinson's disease. Neuromolecular Medicine. Institute of Medicine. (2001). DRIs for Vitamin A, K, and Trace Elements. Razzaque MS, Wimalawansa SJ. (2025). Minerals and human health: deficiency to toxicity. Nutrients.