Lavender (Silexan)

Commonly used for

SleepStressFocus

What is it? / Overview

Silexan modulates voltage-dependent calcium channels in a manner similar to some anti-anxiety medications, without the sedation or dependence risk of benzodiazepines seen in clinical trials.

How is it used? / Administration

Form: Silexan (the specific proprietary lavender oil capsule studied in clinical trials) -- distinct from aromatherapy/topical lavender oil, which has much weaker evidence

Typical dose studied: 80 mg/day (the dose used in Silexan clinical trials)

Timing: Once daily, any time

Silexan is the only lavender preparation with meaningful RCT evidence -- generic 'lavender oil' capsules not standardized to this specific preparation have not been tested the same way and shouldn't be assumed equivalent.

How well does it work? / Evidence

~ Moderate evidence

Who should avoid it?

Interacts with: Sedatives, benzodiazepines, or other CNS depressants -- additive drowsiness

Already taking it? Mild GI upset (burping, nausea) is the most common side effect, often reduced by taking with food.

Research & references

Kasper S et al. (2014). Lavender oil preparation Silexan is effective in generalized anxiety disorder: a randomized, double-blind comparison to placebo and paroxetine. International Journal of Neuropsychopharmacology. Generoso MB et al. (2017). Lavender oil (Silexan) capsules for anxiety: a systematic review and meta-analysis of randomized double-blind clinical trials. Human Psychopharmacology.