Glutathione
Commonly used for
Healthy AgingImmunity
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The cheapest product is usually low quality, but more expensive doesn’t always mean better.
What is it? / Overview
Glutathione is the body's primary intracellular antioxidant. Oral bioavailability has historically been a concern, though some formulations and doses have been shown in human trials to raise body levels to some degree — outcome evidence tied to meaningful health benefit from that increase remains limited.
How is it used? / Administration
Form: Liposomal or S-acetyl glutathione
Typical dose studied: 250–500 mg/day
Timing: On an empty stomach for standard forms; liposomal forms more flexible
Bioavailability remains a genuine consideration. NAC works through a different mechanism (providing a precursor) rather than supplying glutathione directly — it isn't 'universally superior,' just a cheaper, better-evidenced alternative path to the same goal.
How well does it work? / Evidence
? Emerging / limited evidence
Who should avoid it?
Avoid with: Organ transplant (on immunosuppression)
Interacts with: Immunosuppressants
Already taking it? Some human trials suggest certain formulations and doses can raise body glutathione stores, but clinical outcome evidence beyond blood levels remains limited. NAC (already in this database) is a well-evidenced, less expensive way to support the body's own glutathione production, through a different mechanism.
Research & references
Richie JP et al. Oral glutathione supplementation and blood levels. Sinha R et al. Oral glutathione bioavailability review.
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