Elderberry (Sambucus)

Commonly used for
Immunity
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Antiviral support
This is anecdotal, and there isn't strong clinical evidence that it works for everyone.
Elderberry contains anthocyanins with antiviral and immune-modulating properties in laboratory studies, but clinical evidence on immunity benefits is mixed — some small trials and meta-analyses suggest a possible modest reduction in cold/flu symptom duration when started early, while other reviews find the evidence inconclusive. It does not support general infection-prevention claims.
Form: Standardized elderberry extract or syrup (Sambucus nigra)
Typical dose studied: 300–600 mg extract, or syrup per product label, at first sign of illness
Timing: At the first sign of cold/flu symptoms, continued through the illness
Evidence on immunity benefits is mixed, limited to possible symptom-duration effects when started early — not established for preventing infections generally. Caution warranted for anyone on immunosuppressive therapy given its immune-stimulating mechanism.
? Emerging / limited evidence
Avoid with: Organ transplant (on immunosuppression)
Interacts with: Immunosuppressants
Already taking it? Best used at the first sign of symptoms rather than continuously year-round; raw/uncooked elderberry and unripe berries are toxic — only use properly prepared commercial extracts.
Hawkins J et al. (2019). Black elderberry (Sambucus nigra) supplementation effectively treats upper respiratory symptoms: A meta-analysis of randomized, controlled clinical trials. Complement Ther Med. Tiralongo E et al. (2016). Elderberry Supplementation Reduces Cold Duration and Symptoms in Air-Travellers: A Randomized, Double-Blind Placebo-Controlled Clinical Trial. Nutrients.
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