Eggshell Membrane

Commonly used for
Joint Health
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What is it? / Overview
Eggshell membrane supplies collagen and glycosaminoglycans (chondroitin, hyaluronic acid) that are cartilage and synovium components; proposed mechanisms include cartilage support and immunomodulation, reducing inflammatory cytokines and cartilage-degradation markers, with several small trials showing rapid, modest reductions in knee osteoarthritis pain and stiffness.
How is it used? / Administration
Form: Natural eggshell membrane (NEM) or hydrolyzed/water-soluble form (e.g. BiovaFlex) -- contains collagen and glycosaminoglycans
Typical dose studied: 300-500 mg once daily
Timing: Once daily -- symptom improvement is sometimes reported as early as 7-10 days
Derived from eggshell membrane -- the egg-allergy contraindication is worth checking on the label since trace egg protein can remain.
How well does it work? / Evidence
? Emerging / limited evidence
Who should avoid it?
Avoid with: Food Allergies
Already taking it? Reasonable to continue -- consistent small-trial results for pain and stiffness, though several trials are industry-linked and functional-outcome results are less consistent than pain/stiffness results.
Research & references
Ruff KJ et al. (2009). Eggshell Membrane in the Treatment of Pain and Stiffness From Osteoarthritis of the Knee. Clinical Rheumatology. Kiers JL, Bult JHF (2021). Mildly Processed Natural Eggshell Membrane Alleviates Joint Pain Associated With Osteoarthritis of the Knee. Journal of Medicinal Food.
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