DIM (Diindolylmethane)
Commonly used for
Nutrition
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Wellness uses
Estrogen balance
This is anecdotal, and there isn't strong clinical evidence that it works for everyone.
What is it? / Overview
DIM is produced from indole-3-carbinol found in cruciferous vegetables and may influence estrogen metabolism. Human evidence is promising but remains limited, and routine supplementation for hormone balance is not currently supported by strong clinical data.
How is it used? / Administration
Form: Bioavailable DIM, microencapsulated or enhanced-absorption formulations
Typical dose studied: 100–300 mg/day
Timing: With meals
Evidence is weaker than commonly portrayed in marketing. Not a substitute for evidence-based endocrine therapies.
How well does it work? / Evidence
? Emerging / limited evidence
Who should avoid it?
Avoid with: Cancer — active or within past 12 months
Interacts with: Hormonal contraceptives; Hormone replacement therapy; Tamoxifen and other endocrine therapies — consult physician
Already taking it? Avoid combining with hormonal therapies without medical supervision.
Research & references
Reed GA et al. (2008). Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3'-diindolylmethane in healthy subjects. Cancer Epidemiol Biomarkers Prev. Thomson CA et al. (2017). A randomized, placebo-controlled trial of diindolylmethane for breast cancer biomarker modulation in patients taking tamoxifen. Breast Cancer Res Treat.
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