DIM (Diindolylmethane)
Commonly used for
Nutrition
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What is it? / Overview
DIM is produced from indole-3-carbinol found in cruciferous vegetables and may influence estrogen metabolism. Human evidence is promising but remains limited, and routine supplementation for hormone balance is not currently supported by strong clinical data.
How is it used? / Administration
Form: Bioavailable DIM, microencapsulated or enhanced-absorption formulations
Typical dose studied: 100–300 mg/day
Timing: With meals
Evidence is weaker than commonly portrayed in marketing. Not a substitute for evidence-based endocrine therapies.
How well does it work? / Evidence
? Emerging / limited evidence
Who should avoid it?
Avoid with: Cancer — active or within past 12 months
Interacts with: Hormonal contraceptives; Hormone replacement therapy; Tamoxifen and other endocrine therapies — consult physician
Already taking it? Avoid combining with hormonal therapies without medical supervision.
Research & references
Reed GA et al. (2008). DIM single and multiple dose administration. Cancer Epidemiology, Biomarkers & Prevention. Elgar K. (2021). Sulforaphane, DIM and I3C clinical review. Nutritional Medicine Journal. Thomson CA et al. (2017). DIM bioavailability and safety in women. Nutrition and Cancer.
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