D-Chiro-Inositol
Commonly used for
Weight LossMetabolic HealthHormonal Balance
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What is it? / Overview
D-chiro-inositol is involved in insulin signaling and appears to complement myo-inositol in women with PCOS. The strongest evidence supports combination therapy using the physiological 40:1 myo-inositol to D-chiro-inositol ratio.
How is it used? / Administration
Form: D-chiro-inositol, often combined with myo-inositol in 40:1 ratio
Typical dose studied: 300–600 mg/day when used with myo-inositol
Timing: With meals
Should generally accompany myo-inositol rather than be used alone — the 40:1 ratio mirrors normal physiology.
How well does it work? / Evidence
~ Moderate evidence
Who should avoid it?
Interacts with: Diabetes medications — monitor blood glucose
Already taking it? Most evidence supports combining with myo-inositol rather than using D-chiro-inositol alone.
Research & references
Nordio M, Proietti E. (2012). Combined myo-inositol and D-chiro-inositol therapy reduces metabolic disease risk in PCOS. European Review for Medical and Pharmacological Sciences. Bevilacqua A et al. (2019). International Consensus Conference on Myo-inositol and D-chiro-inositol. European Review for Medical and Pharmacological Sciences. International Evidence-based Guideline for PCOS Assessment and Management (2023).
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