Creatine
Commonly used for
EnergyMuscle & StrengthFocusAthletic PerformanceHealthy Aging
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The cheapest product is usually low quality, but more expensive doesn’t always mean better.
What is it? / Overview
Creatine increases your muscles' stored phosphocreatine, allowing you to regenerate ATP more efficiently during short intense efforts. That means better training performance and over time greater gains in strength and lean muscle. It's one of the most thoroughly researched sports supplements available with an excellent safety profile. Creatine isn't just for muscle, either -- the brain relies on the same phosphocreatine-to-ATP system for rapid energy, and supplementation has been linked to improved short-term memory, reasoning, and mental performance, particularly during sleep deprivation, high mental stress, older age, or in people with lower dietary creatine intake such as vegetarians. Evidence in healthy young adults is more mixed, but the overall cognitive picture is promising and comes with the same strong safety profile as creatine's muscle-building use at standard doses.
How is it used? / Administration
Form: Creatine monohydrate (micronized preferred)
Typical dose studied: 3–5 g/day maintenance; optional loading 20 g/day split 4x for 5–7 days
Timing: Any time, consistently; with carbs/protein meal may modestly improve uptake
Monohydrate is gold standard. 1–3 kg weight gain in first weeks is water, not fat. Hydration important. Not a steroid. Creatine HCl (hydrochloride) is a different salt marketed for better solubility and "no loading/no bloating" — a head-to-head RCT and a broader systematic review of alternative creatine forms both found no strength, hypertrophy, or hormonal advantage over monohydrate, which remains the cheapest, most-studied option. No reason to switch from monohydrate to HCl on efficacy grounds.
How well does it work? / Evidence
✓ Well-established
Who should avoid it?
Avoid with: Chronic kidney disease (Stage 3, 4, or 5) — NOT on dialysis; Dialysis (Hemodialysis or Peritoneal Dialysis); Breastfeeding
Interacts with: Nephrotoxic medications (aminoglycosides, cyclosporine, tacrolimus, high-dose NSAIDs)
Already taking it? Continue 3–5 g/day if well tolerated. Avoid loading if already supplementing consistently.
Research & references
Kreider RB et al. (2022). ISSN Exercise & Sports Nutrition Review. JISSN. Candow DG et al. (2023). Creatine in Women's Health: A Lifespan Perspective. Nutrients. Bonilla DA et al. (2024). Creatine plus resistance training for healthy aging. Frontiers in Physiology. Prokopidis K, et al. (2023). Effects of creatine supplementation on memory in healthy individuals: A systematic review and meta-analysis of randomized controlled trials. Nutrition Reviews, 81(4), 416-432.
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