Berberine
Commonly used for
Weight LossHeart HealthMetabolic Health
Where to Buy
Our experts personally review each product we recommend for quality and cost effectiveness.
The cheapest product is usually low quality, but more expensive doesn’t always mean better.
The cheapest product is usually low quality, but more expensive doesn’t always mean better.
What is it? / Overview
Berberine activates metabolic pathways involved in glucose regulation and may improve insulin sensitivity and lipid levels. It can have clinically meaningful effects but also interacts with several medications.
How is it used? / Administration
Form: Berberine hydrochloride
Typical dose studied: 500 mg two to three times daily (1,000–1,500 mg/day)
Timing: With meals
GI side effects common initially — start low. Not a replacement for prescribed diabetes therapy.
How well does it work? / Evidence
~ Moderate evidence
Who should avoid it?
Avoid with: Breastfeeding; End-stage liver disease / Cirrhosis
Interacts with: Diabetes medications — risk of hypoglycemia; Cyclosporine; Anticoagulants
Already taking it? Monitor blood glucose carefully to avoid hypoglycemia.
Research & references
Yin J et al. Berberine and type 2 diabetes. Cicero AFG et al. Berberine metabolic effects. ADA adjunctive evidence discussions on berberine.
Disclosure: Knozela is a participant in the Amazon Associates affiliate program. Some "Where to buy" links on this page are affiliate links -- if you make a purchase through them, Knozela may earn a commission at no additional cost to you.