Apigenin
Commonly used for
SleepStress
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What is it? / Overview
Apigenin binds the benzodiazepine site of GABA-A receptors, indirectly opening chloride channels and hyperpolarizing neurons -- a plausible anxiolytic and sedative mechanism, and the presumed basis for chamomile's calming reputation. Human data for isolated apigenin specifically are lacking.
How is it used? / Administration
Form: Isolated apigenin flavonoid -- also the key active constituent of chamomile
Typical dose studied: No validated human dose for isolated apigenin (commonly ~50 mg in sleep-stack products)
Timing: Before bed
Best cross-referenced to chamomile if that entry exists in the database -- apigenin is chamomile's presumed active constituent, not an independently trial-validated isolate.
How well does it work? / Evidence
? Emerging / limited evidence
Who should avoid it?
Avoid with: Breastfeeding; Bleeding disorder / Coagulopathy
Interacts with: CNS depressants, benzodiazepines, alcohol -- theoretical additive sedation; CYP-metabolized drugs -- apigenin inhibits some CYP enzymes in vitro; Anticoagulants -- theoretical additive bleeding risk
Already taking it? Reasonable, low-risk to continue -- best understood as the active compound behind chamomile's calming reputation rather than an independently validated standalone sleep aid, since isolated-apigenin human trials are essentially absent.
Research & references
Savage K et al. (2018). GABA-modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence. Phytotherapy Research.
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