Alpha-Lipoic Acid (ALA)
Commonly used for
Metabolic HealthNerve Health
Where to Buy
Our experts personally review each product we recommend for quality and cost effectiveness.
The cheapest product is usually low quality, but more expensive doesn’t always mean better.
The cheapest product is usually low quality, but more expensive doesn’t always mean better.
What is it? / Overview
Alpha-lipoic acid is a potent antioxidant involved in mitochondrial energy production. It has the strongest evidence for improving symptoms of diabetic peripheral neuropathy and may modestly improve insulin sensitivity.
How is it used? / Administration
Form: R-alpha-lipoic acid (R-ALA) preferred; standard ALA also effective
Typical dose studied: 300–600 mg/day
Timing: 30 minutes before meals or on empty stomach
R-ALA is more bioavailable but often more expensive. Take away from meals for better absorption.
How well does it work? / Evidence
~ Moderate evidence
Who should avoid it?
Avoid with: Alcohol use disorder
Interacts with: Diabetes medications — monitor for hypoglycemia; Thyroid medications
Already taking it? Monitor blood glucose if combined with glucose-lowering therapy. Correct any existing thiamine deficiency first -- ALA can accelerate thiamine depletion.
Research & references
Ziegler D et al. ALA and diabetic neuropathy. ADA adjunctive evidence on ALA. Cochrane Reviews on ALA for diabetic neuropathy.
Disclosure: Knozela is a participant in the Amazon Associates affiliate program. Some "Where to buy" links on this page are affiliate links -- if you make a purchase through them, Knozela may earn a commission at no additional cost to you.