Acetyl-L-Carnitine (ALCAR)
Commonly used for
EnergyFocusHealthy Aging
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Wellness uses
Nerve comfort
This is anecdotal, and there isn't strong clinical evidence that it works for everyone.
What is it? / Overview
Acetyl-L-carnitine transports fatty acids into mitochondria for energy production and may help support nerve regeneration. It has the strongest evidence for diabetic and chemotherapy-induced peripheral neuropathy with more modest evidence for cognitive support.
How is it used? / Administration
Form: Acetyl-L-carnitine hydrochloride
Typical dose studied: 500–2,000 mg/day in divided doses
Timing: Morning or early afternoon with or without food
ALCAR crosses the blood-brain barrier more readily than L-carnitine. May cause mild GI upset in some individuals.
How well does it work? / Evidence
~ Moderate evidence
Who should avoid it?
Avoid with: Epilepsy / Seizure disorder; Hypothyroidism / Hashimoto's thyroiditis
Interacts with: Warfarin — rare interaction reports; Thyroid hormone replacement — consult clinician
Already taking it? Assess benefit after approximately 8–12 weeks.
Research & references
Li S et al. (2016). Effects of acetyl-L-carnitine and methylcobalamin for diabetic peripheral neuropathy: A multicenter, randomized, double-blind, controlled trial. J Diabetes Investig. Sima AAF et al. (2005). ALCAR improves pain and nerve regeneration in diabetic neuropathy. Diabetes Care. Montgomery SA et al. (2003). Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer's disease. Int Clin Psychopharmacol.
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